amlodipine and benazepril

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Pronunciation: am LOE di peen and ben AY ze pril

Brand: Lotrel

Amlodipine-Benazepril 10 mg-20 mg-TEV

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capsule, blue, imprinted with TEVA 7373

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Amlodipine-Benazepril 10 mg-40 mg-TEV

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capsule, blue, imprinted with TEVA, 7671

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Amlodipine-Benazepril 2.5 mg-10 mg-TEV

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capsule, white, imprinted with TEVA, 7370

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Amlodipine-Benazepril 5 mg-10 mg-TEV

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capsule, orange/white, imprinted with TEVA, 7371

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Amlodipine-Benazepril 5 mg-20 mg-TEV

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capsule, pink/white, imprinted with TEVA 7372

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Amlodipine-Benazepril 5 mg-40 mg-TEV

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capsule, blue, imprinted with TEVA, 7670

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Lotrel 10 mg-20 mg

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capsule, purple, imprinted with LOTREL 0364

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Lotrel 10-40 mg

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capsule, blue, imprinted with Lotrel 0379

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Lotrel 2.5-10mg

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capsule, white, imprinted with LOTREL 2255

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Lotrel 5 mg-10 mg

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capsule, orange, imprinted with LOTREL 2260

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Lotrel 5-10mg

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capsule, brown, imprinted with LOTREL 2260

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Lotrel 5-20

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capsule, pink, imprinted with LOTREL 2265

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Lotrel 5-40 mg

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capsule, blue, imprinted with Lotrel, 0384

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What is the most important information I should know about amlodipine and benazepril?

Do not use if you are pregnant. If you become pregnant, stop taking this medicine and tell your doctor right away.

You should not use this medicine if you have ever had angioedema (hives or severe swelling of deep skin tissues sometimes caused by allergic reaction).

If you have diabetes, do not use amlodipine and benazepril together with any medication that contains aliskiren (Amturnide, Tekturna, Tekamlo).

What is amlodipine and benazepril?

Amlodipine is a calcium channel blocker. Amlodipine relaxes (widens) blood vessels and improves blood flow.

Benazepril is an ACE inhibitor. ACE stands for angiotensin converting enzyme. Benazepril also widens blood vessels and also prevents the body from retaining water.

Amlodipine and benazepril is a combination medicine used to treat high blood pressure (hypertension).

Amlodipine and benazepril may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking amlodipine and benazepril?

You should not use this medicine if:

  • you are allergic to amlodipine (Norvasc, Caduet, Exforge, Lotrel, Tekamlo, Tribenzor, Twynsta, Amturnide) or benazepril (Lotensin);
  • you have ever had angioedema (hives or severe swelling of deep skin tissues sometimes caused by allergic reaction); or
  • you are allergic to any other ACE inhibitor, such as captopril (Capoten), fosinopril (Monopril), enalapril (Vasotec), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), ramipril (Altace), or trandolapril (Mavik).

If you have diabetes, do not use amlodipine and benazepril together with any medication that contains aliskiren (Amturnide, Tekturna, Tekamlo).

You may also need to avoid taking amlodipine and benazepril with aliskiren if you have kidney disease.

To make sure amlodipine and benazepril is safe for you, tell your doctor if you have:

  • kidney disease (or if you are on dialysis);
  • liver disease;
  • heart disease or congestive heart failure;
  • a connective tissue disease such as Marfan syndrome, Sjogren's syndrome, lupus, scleroderma, or rheumatoid arthritis;
  • if you are on a low-salt diet.

Do not use if you are pregnant. If you become pregnant, stop taking this medicine and tell your doctor right away. Benazepril can cause injury or death to the unborn baby if you take the medicine during your second or third trimester.

Amlodipine and benazepril can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are using this medicine.

How should I take amlodipine and benazepril?

Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Amlodipine and benazepril can be taken with or without food. Take the medicine at the same time each day.

Vomiting, diarrhea, or heavy sweating can cause you to become dehydrated. Drink plenty of water each day while you are taking this medicine.

Your blood pressure will need to be checked often. You may also need frequent blood tests at your doctor's office.

If you need surgery, tell the surgeon ahead of time that you are using amlodipine and benazepril. You may need to stop using the medicine for a short time.

You may have very low blood pressure while taking this medicine. Call your doctor if you are sick with vomiting or diarrhea, or if you are sweating more than usual. Prolonged illness can lead to a serious electrolyte imbalance, making it dangerous for you to use amlodipine and benazepril.

Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If you are more than 12 hours late, skip the missed dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking amlodipine and benazepril?

Drinking alcohol with this medicine can cause side effects.

This medicine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Do not use salt substitutes or potassium supplements while taking amlodipine and benazepril, unless your doctor has told you to.

What are the possible side effects of amlodipine and benazepril?

Get emergency medical help if you have signs of an allergic reaction: hives; severe stomach pain; difficulty breathing; swelling of your face, lips, tongue, or throat. You may be more likely to have an allergic reaction if you are African-American.

Some side effects may not occur until after you have used the medicine for several months.

Call your doctor at once if you have:

  • a light-headed feeling, like you might pass out;
  • swelling in your hands or feet, rapid weight gain;
  • new or worsened chest pain;
  • fever, chills, sore throat, body aches, flu symptoms;
  • high potassium --nausea, slow or unusual heart rate, weakness, loss of movement; or
  • liver problems --nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Common side effects may include:

  • cough;
  • dizziness; or
  • headache.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect amlodipine and benazepril?

Many drugs can interact with amlodipine and benazepril. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any you start or stop using, especially:

  • gold injections to treat arthritis;
  • a shot for bee-sting allergy;
  • lithium;
  • simvastatin;
  • medicine to prevent organ transplant rejection, such as everolimus, sirolimus, or tacrolimus;
  • a nonsteroidal anti-inflammatory drug (NSAID) such as ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others;
  • a potassium supplement such as K-Dur, Klor-Con;
  • salt substitutes that contain potassium; or
  • a diuretic (water pill).

This list is not complete and many other drugs can interact with amlodipine and benazepril. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.

Where can I get more information?

Your pharmacist can provide more information about amlodipine and benazepril.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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