News for Healthier Living

Neutrophil-Derived THBS1 Signals Through Epithelial CD36-JNK to Disrupt the Intestinal Barrier

A new study in mice shows that neutrophils, a type of immune cell, can signal intestinal epithelial cells to undergo apoptosis after blood flow returns to the gut. This signaling can disrupt the intestinal barrier, allowing bacteria and inflammatory factors to enter the body. When researchers removed or blocked the signal, the barrier was better preserved and inflammation was lower. The study used single-cell sequencing, genetic deletion, and drugs to identify the signal and test whether blocking it protects the intestine. It focuses on early ischemia-reperfusion injury, when immune cells enter the gut and can damage epithelial cells. The results suggest a possible target for limiting gut barrier injury in severe burns, shock, and other critical conditions.

October 14, 2026


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