News for Healthier Living

The Developing Nervous System, Acetaminophen Effects, and More Are in the Spotlight in the June 2025 Issue of ToxSci

The June 2025 issue of Toxicological Sciences includes an In-Depth Review that shares a neuroscience perspective on the use of new approach methodologies in developmental neurotoxicity testing, while a Research Brief explores the safety of acetaminophen exposure during gestation.

June 6, 2025

June 14 2025

• Building Strength May Take Less Exercise Than You Think

June 13 2025

• A Father's Gift: Dr. Kurz's Double Duty Healing Patients & Giving the Gift of Life
• Advancing Neuroscience Research with High-Speed, Automated Electrophysiology
• To Understand Alzheimer's Disease, Researchers Turn to Myelin Sheath
• Inside the Simulation Center at Children's Hospital Los Angeles
• FDA Approves Immune Checkpoint Inhibitor Drug for Patients with Resectable Locally Advanced Head and Neck Cancer, Backed by Dana-Farber Research
• Alcohol Use Disorder Harms the Brain's Immune System Earlier in Women
• Alcohol-Linked Liver Deaths Rising in Women and Young Adults
• "The Most Human Gesture" Brings the Gift of a Hand Transplant at Penn Medicine
• More Than 460 CDC Workers Reinstated After Layoffs
• Former MTV Host Ananda Lewis Dies at 52 After Breast Cancer Battle
• Children With Acute Allergic Reactions Often Spend Unnecessary Time in Hospitals
• UH Harrington Heart & Vascular Institute First Site in Ohio to Provide More Accurate and Convenient PET MPI Cardiac Stress Test
• Immunotherapy: A New Target Found
• Lack Of Sleep Alters Teens' Brains, Potentially Promoting Behavior Issues
• Microbiome Linked To Memory Issues, Dementia In Parkinson's Patients
• Childhood Trauma Boosts Endometriosis Risk
• Mild Sleep Apnea More Common Among Female Athletes Than Thought
• 'Forever Chemicals' Linked To Elevated Childhood Blood Pressure
• CT Scans Outperform DNA Stool Tests In Colon Cancer Screening, Study Says
• Toward Precision Wound Care
• SGLT2 Inhibitor Empagliflozin Treatment Stabilizes Kidney Function in Patients Who Have Had a Heart Attack
• Vaccinated Patients Hospitalized with COVID-Linked Acute Kidney Injury Less Likely to Need Dialysis, and More Likely to Survive, After Discharge
• Among New Dads, 64% Take Less Than Two Weeks of Leave After Baby Is Born
• Hemophilia B Gene Therapy Demonstrates Long-Term Success

June 12 2025

• Money Names CSUF's Graduate Nursing Programs Among Nation's Best in 2025
• A Common Heart Failure Treatment Comes with High Risk of Stroke. But a New Discovery Could Make It Safer
• RFK Jr. Installs Critics on Vaccine Recommendation Panel
• This Father's Day: Give Dad The Gift Of Health, Schedule Important Health Screenings
• Defying the Odds: Father's Love Leads to Life-Changing Surgery
• RFK Jr. Hires Autism Skeptic To Look Into CDC Autism Data
• New Antibody Shot Could Help Protect Babies From RSV
• From Basic Research to Clinic: Both Diagnostic and Therapeutic Use of the Microbiota Will Become Reality Within the Next 5-10 Years
• Zicam and Orajel Swabs Recalled for Possible Fungal Contamination
• Knee Injuries: Causes and Symptoms
• Study Highlights Role of Jaundice-Associated Pigment in Protecting Against Malaria
• Turning Back Time on Muscle Stem Cells to Prevent Frailty From Aging
• University Hospitals Orthopedic Physicians Ranked Among the Best in the Nation for Research, According to Avant-Garde Health
• Holiday Heart: The Overindulgences During Festival Season That Put Even Healthy People at Risk
• Smartphone App Can Track Huntington's Disease Symptoms
• Mapping How Nutrients Move Through the Body to Treat Cancer
• Screen Time And Troubled Kids: Is There A Vicious Circle?
• Most People Open To Sharing Smartwatch Health Data With Doctors
• Misconceptions Abound Regarding High Blood Pressure, Poll Finds
• Accelerated Biological Aging Tied To Dementia, Stroke Risk
• Bisexual, Gay and Lesbian Medical Students Less Likely To Finish School
• Study Finds Seniors Are Money Savvy - Until Dementia Sets In
• Smart Contact Lens Keeps an Eye on Your Eyes--Even When They're Closed

June 11 2025

• Why Caffeine Might Hold the Key to Preventing Sudden Infant Death Syndrome
• Eating More Fruits and Veggies Could Help You Sleep Better
• UAlbany Neuroscientist Explores Early Alzheimer's Progression, How Our Internal Clock Affects Learning and Memory
• FDA Approves Polypill Widaplik for Hypertension
• Stroke, Dementia More Common in People with Biomarker of Aging
• Rutgers Health Researchers Challenge FDA Warning on Common Epilepsy Drug
• New Digital Marker Could Improve Childhood Asthma Detection
• Children's Research Institute Scientists Uncover Unique Pathway Tumors Use to Acquire Antioxidant Lipids
• VIDEO AND TRANSCRIPT AVAILABLE: Advances in Ankle Replacement - Virtual Briefing
• FDA Plans to Use AI to Speed Up Drug and Food Safety Reviews
• MD Anderson Research Highlights for June 11, 2025
• Pointing to Success: Marathon Potential Is in Your Hands - Literally
• These Smiling Salamanders Are Helping Scientists Learn to Regrow Limbs
• Midea Recalls 1.7 Million AC Units Over Mold Risk
• Feedback for Surgeons Curbs Excess Opioid Prescriptions Scripts
• A New Look at the Stateville Prison Malaria Experiments
• First-of-Its-Kind Technology Helps Man with ALS 'Speak' in Real Time
• HPV Drives Tumor Development in Rare Nasal Cancers
• American College of Surgeons Accreditation Process Drives Quality Improvement, Study Shows
• Inflammatory Bowel Disease Info Lacking On TikTok
• Biking Might Promote Healthy Brain Aging
• Real-World Results For GLP-1 Drugs Underwhelm, Study Says
• 'Latchkey Incontinence' Treatments Might Include Mindfulness Meditation
• At-Home HPV Testing Boosts Cervical Cancer Screening Rates
• Abortion-Ban States Provide Worse Health Care To Pregnant Women, Study Says
• 12th Annual Insomnia Awareness Night Highlights Chronic Insomnia Symptoms, Treatment
• New ACG Clinical Guidelines on Crohn's Disease and Ulcerative Colitis in June Issue of AJG
• New JNCCN Study Showcases how Telehealth Helps Overcome Geographic and Resource Gaps in Cancer Care Globally
• Green Light Activates This Antibiotic Only Where It's Needed
• CRISPR Technologies: Revolutionizing Regenerative Medicine
• Multiphoton Polymerization: A Promising Technology for Precision Medicine
• Pancreatic Cancer Vaccines Eliminate Disease in Preclinical Trials
• Boosting Precision Gene Editing: Autophagy Turns the Tide on DNA Repair
• Improving Maternal Outcomes with Respectful Maternity Care

June 10 2025

• New Study Shows Outstanding Long-Term Outcomes for Zimmer Total Ankle Replacement Using Unique Lateral Approach
• New Treatment for C. Diff. Infection May be Less Effective Than Traditional Therapy, Study Finds
• Teens With Heavy Menstruation Don't Need to Suffer in Silence -- Period
• AMA Passes Resolution Calling for Expanded Access to Anti-Obesity Medications
• Study Shows Sharp Increase in Appendix Cancer for Generation X and Millennials
• Deep Vein Thrombosis - Sidelining Young Athletes
• American College of Surgeons President Beth H. Sutton Inspires Foster School of Medicine with Vision of Collaborative Surgical Excellence
• Fatal School Shootings Have Lasting Impact on Local Economies
• Study Identifies the 'Sweet Spot' for Catch-Up Sleep by Teens on Weekends
• CHLA Infant the Youngest-Ever Liver Transplant Recipient in California
• Two Rutgers Teams Trace Brain Circuits That Tell Us When to Eat - and When to Stop
• FDA Approves Sonu Band for Drug-Free Treatment of Pediatric Nasal Congestion
• Study Reveals Disparities in Mental Health Care for Texas Youth
• Cannabis Use Disorder May Increase Risk For Certain Psychiatric Illnesses
• Cutting-Edge Technology Expands Dictionary of Human Metabolism
• Bioprinted Aorta Shows Promise for Cardiovascular Disease Treatment
• Child Gun Deaths Rose in States With Weaker Laws After U.S. Supreme Court Decision
• RFK Jr. Removes Entire CDC Vaccine Advisory Panel
• BowFlex Recalls 3.8 Million Dumbbells After Injury Reports
• Grassroots Solutions Key to Boosting Health Support for Aussie Bush Kids
• New Study Shows Outstanding Long-Term Outcomes for Zimmer Total Ankle Replacement Using Unique Lateral Approach
• VIDEO AND TRANSCRIPT AVAILABLE: National Cancer Survivors Month Expert Panel
• Healthy Sleep Patterns in Adolescence Predict Better Cardiovascular Health in the Future
• Johns Hopkins Medicine Study Finds Eating 'DASH for Diabetes' Lower-Sodium Diet Can Produce Clinically Meaningful Reduction in Blood Pressure for People with Type 2 Diabetes
• Kids Snooze Soundly In Happy Families
• Racial Disparities Driving Emergency Surgery Costs
• Blood Tests Can Detect Cancer Years Earlier
• Statins Appear Effective In Treating Sepsis
• Yale Researchers Identify New Biomarker Panel to Assess Risk of Chronic Kidney Disease Progression in Children
• Are You Ruining Your Child's Chance To Avoid Food Allergies?
• Advice In Teen TikTok Beauty Videos Can Lead To Skin Damage
• People with COVID-Like Symptoms Took Up to Nine Months Post-Infection to Regain Mental Well-Being
• Less is More: To Build Muscle and Gain Strength, Train Smarter - Not Longer
• All in for Attendance: Education and Public Health Leaders Release Framework to Address Chronic Absence from Schools
• Cleveland Clinic is First to Use Wireless, Catheter-Free Device to Monitor Bladder Dysfunction in Patients
• Cleveland Clinic Research Finds Injectable Medications for Obesity Produce Smaller Weight Loss in A Real-World Setting, Compared to Randomized Clinical Trials

June 9 2025

• UC San Diego Researchers Find Evidence of Accelerated Aging in Children with Multiple Sclerosis
• Patients Are Opting in for 10 Years of Breast Cancer Treatment
• IU School of Medicine Research Helps Lead to FDA Clearance of First Blood Test for Alzheimer's Disease
• New Method of Biofabrication Could Advance Tissue Engineering, Bioprinting
• Smart Microbes Use Pathogenic Tools to Deliver Therapeutics
• Appendix Cancer Incidence Has Quadrupled in Older Millennials
• Experts Debate Management of Patient with Knee Osteoarthritis Interested in Total Knee Joint Arthroplasty
• Study Defines Key Driver of Aggressive Ovarian Cancer
• Ex-White House Doctor Says Biden Should Have Had a Cognitive Test
• Celebrity Diagnoses Underscore Rising Breast Cancer Rates in Young Women
• Salmonella Outbreak Triggers Egg Recall in 9 States
• Texas Woman Dies After Using Tap Water in Sinus Rinse
• Protein Pivotal for B-Cell Cancers Gets a Closer Look
• Orthodontists Testing Innovative Technology for Making 'Shape Memory' Dental Aligners
• Cracking the Spatial Code: A New Chapter in Bone and Muscle Research
• Don't Sweat The Weight — Healthy Eating Helps Your Heart Regardless
• Proper Folding Is Important for a Protein Associated with Seizures
• CPAP Or Zepbound? Patients, Doctors Debate Sleep Apnea Treatment
• Combo Drug Treatment More Effective For Kidney Disease in Type 2 Diabetics
• AI Can Boost Radiologists' Efficiency Without Sacrificing Accuracy
• Lack of Sleep Disrupts Key Brain Functions in Adolescents
• This Easier-To-Follow Diet Might Help IBS Patients, Study Says
• Fewer People Seeking Treatment For Cannabis Use Disorder
• Engineers Develop Genetic Testing Device to Detect Rare Mutations
• Juju Goes Home!
• Could Electric Fields Supercharge Immune Attack on the Deadliest Form of Brain Cancer?
• Rutgers Health Research Identifies New Trigger Accelerating Antibiotic Resistance

June 8 2025

• A Gene May Influence How Much Cats Purr and Meow
• Mount Sinai Experts Present Research at SLEEP 2025

June 7 2025

• An Expert's Guide to Keeping Middle-Age Spread at Bay

June 6 2025

• Find Peace by Confronting Your Inner Demons--Virtually
• Children Affected by Wildfires Navigate New Disruption: Summer
• New Understanding of Protein Processing Could Have Implications for Alzheimer's and Some Cancers
• First Patient Treated with Federally Approved Lyfgenia(tm) for the Curative Gene Therapy Treatment of Sickle Cell Disease Leaves Joseph M. Sanzari Children's Hospital at Hackensack University Medical
• Research Tip Sheet: AI, Gene Therapy, Heart and Medication Studies
• The Developing Nervous System, Acetaminophen Effects, and More Are in the Spotlight in the June 2025 Issue of ToxSci
• Nurses Speak Out: Fixing Care for Disadvantaged Patients
• Long-Lasting HIV Prevention Shot Headed Toward Approval
• 4 States Ask FDA to Lift Rules on Abortion Pill Mifepristone
• Uncovering How Cells Allocate Space to Make Way for New Growth
• Toothbrush-Shaped Ultrasound Allows for Gum Monitoring
• ESPN's Jay Harris Diagnosed With Prostate Cancer
• Immunotherapy Effective Against Stomach Cancer
• Teenage 'Night Owls' More Likely To Act Impulsively
• Freshwater U.S. Fish Carry Parasitic Flatworm That Can Infect Humans
• There's A Better Clot-Preventing Option Than Aspirin, Researchers Say
• Interrupted Sleep Plagues New Mothers
• Diabetes Drug Effective For Fatty Liver Disease
• Mayo Clinic researchers validate blood test to diagnose Alzheimer's disease in outpatient memory clinics
• How to Talk to Your Child About Cancer in a Loved One

June 5 2025

• Why Some Kids Respond Better to Myopia Lenses? Genes Might Hold the Answer
• Increasing Numbers of US Adults Don't Know They Have Diabetes, High Blood Pressure or High Cholesterol, Study Shows
• Expanded Child Tax Credit Helped Middle-Class Families Pay Energy Bills, but Not the Poorest
• UTSW Scientists Link Another Gene to Obesity
• Organic Ground Beef Sold at Whole Foods May Be Contaminated With E. Coli, USDA Says
• More U.S. Teens Are Now Taking Wegovy for Weight Loss
• RFK Jr. Calls for a Review of Abortion Pill Mifepristone
• Q&A: Advancing Fetal Cardiology Care for Babies and Families
• Weight Stigma Tied To Lingering Depression, Anxiety After Weight-Loss Surgery
• Jail Time Increases A Person's Risk of Death
• Naps Associated With Increased Risk Of Death
• Crisis Pregnancy Centers Draw Fair Share of Younger Women, Study Says
• New Sugar-Based Test Can Suss Out Snake Venoms
• Fido Might Protect Your Baby Against Eczema
• Lower BMI Doesn't Improve Mental Health After Weight-Loss Surgery. Here's What Does
• An Ultrasound Scan of the Baby's Heart at the Onset of Labour Is Useful for Safe Childbirth
• EGFR Inhibitor-Linked Cytokine Storms: Study Uncovers the Trigger
• Children's Hospital of Philadelphia Researchers Show Quality Improvement Initiative in the Emergency Department Improved Family Engagement Around Firearm Safety Resources
• VUMC Icon Mildred Stahlman to Figure in 'Monumental' Exhibit at Nashville's Parthenon
• Cancer Research Institute Publishes Inaugural 2025 Cancer Immunotherapy Insights + Impact Report
• The Price of a Peek: Retinal Damage After the 2024 Solar Eclipse

June 4 2025

• Relationship Insecurity Is the Link Between Poor Sleep and Feelings of Jealousy
• Study Finds Carbon Stable Isotope Values Yield Different Dietary Associations with Added Sugars in Children Compared to Adults
• New Study: Personalized Exercise Boosts Health for People with Neuromuscular Disease
• American Neurological Association Announces Key Plenaries for the Celebratory 150th Annual Meeting September 13-16, 2025, in Baltimore
• Proinflammatory Foods Tied to Higher Risk of Death in Colon Cancer Patients
• Study Uncovers How Biomolecular Condensates Cause Some Kidney Cancers
• Most-Viewed TikTok Videos on Inflammatory Bowel Disease Show Low Quality
• Loss of Y Chromosome Leads to Poor Cancer Outcomes
• Which Mesh is Best? Outcomes for Abdominal Ventral Hernia Repair Patients Projected by New Research Model
• Consuming Less Cysteine Can Burn Fat to Induce Weight Loss
• Would You Hand Over Your Health Data if It Meant Better Care?
• Judge Says Transgender Inmates Must Have Access to Hormone Therapy
• Pepto Bismol May Not Prevent Traveler’s Diarrhea, New Study Finds
• Coffee Could Be Key To Aging Gracefully
• High Insulin Linked To Irregular Periods
• How Do Low-Calorie Diets Affect A Person's Mood?
• A New Pitt Study Has Upended Decades-Old Assumptions About Brain Plasticity
• How Does A Pregnant Woman's Weight Influence Her Child's Infection Risk?
• Preemptive Kidney Transplants Add No Benefit, Study Says
• Troubled Kids Wait a Half-Day — Or More — In ER To Get Mental Health Care
• Tip Sheet: A New Treatment for Metastatic Colorectal Cancer, Discoveries for Small Cell Lung Cancer -- and a State-of-the-Art Learning Lab for Community Education
• 'Eye' on Health: AI Detects Dizziness and Balance Disorders Remotely
• AI-Powered Mammography Yields Major Gains in Cancer Detection and Diagnostic Accuracy, New Study Finds
• Research Grid's Artificial Intelligence Automates a 3-Year Queen Mary Clinical Trial in Seconds
• Does Your Child Suffer from Migraines? Ways You Can Help
• Real-Time 3D Visualization Reveals Potent Antibacterial and Antibiofilm Activity Against Superbacteria

June 3 2025

• Emergency Surgeries Cost More--and Racial Disparities Are Driving Up the Bill
• Annual Alzheimer's Clinical Trials Pipeline Report Shows Increased Reason for Optimism
• Histotripsy Stimulates the Immune System to Attack Cancer Cells Outside the Liver
• Some Storms Leave Emotional Damage: How to Cope After a Traumatic Weather Disaster
• Five-Year Analysis Shows Immunotherapy Plus Chemotherapy Before Lung Cancer Surgery Significantly Improves Long-Term Survival
• 5 Trends Impacting Adolescent Idiopathic Scoliosis Care
• Moderna's New Lower-Dose COVID-19 Vaccine Approved by FDA
• Evidence-Based Animated Video Series Raises Epilepsy Awareness, Dispels Myths in Eastern Mediterranean Region
• Outdoor Medicine Expert Shares Tips to Reduce Tick Bite Risk
• Researchers Develop Innovative Model To Study Sense of Smell
• Wearing Hearing Aids May Help Delay Dementia, Especially for Those at Higher Risk, UCLA Expert Says
• Bronchiolitis, Monoclonal Antibody Halves Hospitalizations of Children Younger Than Six Months Old
• Parental Engagement Associated with Better Sleep in Pre-Teen Children
• How Late College Students Go to Sleep Is Influenced by the Need to Belong
• Study Identifies Personality Traits Associated with Bedtime Procrastination
• CDC Now Says Americans Traveling Abroad Should Get Measles Shots First
• Study Finds Powerful Sweetener in Vapes Marketed to Teens
• Tiny Baby’s Life-Threatening Wound Healed With Fish Skin
• How Can A Daily Cup Of Beans Improve Your Health?
• Being Incarcerated and Living in Areas Where More Have Gone to Jail Is Associated with Higher Death Rates
• Eating More Phytosterols Could Lower Your Risk of Heart Disease and Diabetes
• Eating More Sweet Food May Not Sway Sweet Preference
• Scientists Propose New Approach for Classifying Processed Foods
• Self-Employment Is Good For Heart Health, Especially For Women
• More Seniors Are Regular Weed Users
• Digital Screening During Primary Care Visits May Lead to Earlier Dementia Detection, Care
• Vape Package Warnings Can Deter Use, But Current Rules Are Lacking
• Breast Cancer Screening In Women's 40s Can Save Lives, Study Says
• Measles Vaccinations Declining Throughout U.S.
• Freshwater Fish in U.S. Carry Introduced Human-Infecting Parasites
• Study Finds Daily Cup of Beans Boosts Heart and Metabolic Health
• International Study: Asthma Drug Could Help to Treat a Rare Neurological Disorder

June 2 2025

• Yale Study: Wearable Intervention for Alcohol Use Risk and Sleep in Young Adults
• Breast Cancer: A New Target to Eliminate Dormant Cells Before They Wake
• Do MicroRNAs Hold the Key to Psychiatric and Neurodegenerative Disorders?
• LLNL Researchers Use AI to Look for Potential ALS Treatments
• Mediterranean Diet Provides Symptom Relief for Patients with IBS in Pilot Study
• Advancing Personalized Medicine Through Pharmacogenomics: Insights From Ochsner Health
• Police Spending Linked to Shorter Lives for Black Americans
• Professor Antonio Giordano Appointed to Italy's Highest Public Health Advisory Body
• FDA Approves Tryptyr Eye Drops for Dry Eye Disease
• Border Health Telemedicine Program is a Game Changer for Student Health in Far West Texas Schools
• Excessive Daytime Sleepiness Is Associated with Mortality in Middle-Aged Women
• Cognitive Outcomes Similar After Noncardiac Surgery Whether Perioperative Hypotension- or Hypertension-Avoidance Strategies Employed
• ACP Leaders Warn That Abrupt Changes to COVID-19 Vaccine Recommendations Could Jeopardize Payment Coverage and Place Millions of Americans at Risk
• Circadian Preference Is Associated with Impulsivity in Adolescents
• Comorbid Obesity and Sleep Apnea Treatment Preferences Differ Among Patients and Providers
• ASCO: New Antibody-Drug Conjugate Shows Promising Safety and Response Rates for Patients with Rare Blood Cancer
• Fighting Myeloma with Fiber: Plant-Based Diet Offers Promise
• What Makes Someone Leave a Medicare Advantage Plan?
• FDA Issues Highest Alert Over Tomato Recall in 3 Southern States
• Cucumber-Linked Salmonella Outbreak Sickens Dozens Across 18 States
• Exercise Cuts Colon Cancer Recurrence and Boosts Survival, Study Finds
• Fruit Flies on Cocaine Could Reveal Better Therapies for Addiction
• Researchers Find Early Driver of Prostate Cancer Aggressiveness
• Eating Healthier Can Protect Aging Brain
• Brewed for Longevity: Drinking Coffee Linked with Healthy Aging in Women
• Cancer Treatment 'Brain Drain' Occurring In Rural Areas
• Fluoride Ban Could Create Cavities For 1 Of Every 3 U.S. Kids
• Wildfire Smoke Dents Survival Odds For Lung Cancer Patients
• Can A Vegan Diet Reduce Menopause Symptoms?
• CHLA-Led Behavioral Health Team Receives $6.4 Million Research Grant for Clinical Trial on Combined Treatments for Pediatric Anxiety
• Could Poverty Trigger the Next Pandemic?
• Dads Help Shape Eating Habits of Their Children
• It's Not Too Late to Start Eating Better for Your Brain
• Ticks Are Surging and Spreading Across the U.S. - Here's How to Protect Yourself

June 1 2025

• Immunotherapy Boosts Chemotherapy in Combating Stage 3 Colon Cancer
• Not-So-Tasty: Plastic Particles Found in Food Could Harm the Body
• How Caffeine Affects Your Brain While You Sleep
• For Heart Health, Food Quality Matters More than Cutting Carbs or Fat
• Study Suggests Obesity Contributes to Anxiety and Cognitive Impairment
• Higher Linoleic Acid Levels Linked to Lower Heart Disease and Diabetes Risk
• Dual-Target CAR T Cell Therapy Slows Growth of Aggressive Brain Cancer
• Diet Influences Survival After Stage III Colon Cancer, Dana-Farber Study Finds
• Adding Immune Checkpoint Inhibitor to Standard Chemotherapy Regimen Improves Outcomes in Stage 3 Colon Cancer, Study Finds
• Denver Hospital's Bra Project Prevents Wounds in Women After Sternotomy
• AI Deciphers Plant DNA: Language Models Set to Transform Genomics and Agriculture
• June 2025 Issue of Neurosurgical Focus: "Scoliosis Surgery in Adults"